Department of Chemistry and Chemical Biology
Experimental molecular evolution
It is widely believed that mutations shape the organismal fitness landscape through their effects on protein stability. Hence, destabilizing mutations are expected to have detrimental effects on fitness. In the recent work from the lab, it has been observed that the effect of such destabilizing mutations can be compensated by gain in stability though oligomerization (see this article). My research work focuses on testing the universality of this mechanism by modulation of various in vivo parameters in other essential protein using an integrative approach of molecular biology, biophysics and genetics.