Energy Profile of the Space of Model Protein Sequences

Citation:

Tiana, G., Broglia, R.A. & Shakhnovich, E.I. Energy Profile of the Space of Model Protein Sequences. Journal of Biological Physics 27, 2-3, 147 - 159 (2001).

Date Published:

2001

Abstract:

A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.

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