Sensitivity-dependent model of protein–protein interaction networks

Date Published:

2008

Abstract:

The scale free structure p(k) ~ k−γ of protein–protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and find the key reason for the model generating apparent scale free degree distributions. This explanation provides a generic mechanism of 'scale free' networks. Moreover, we predict the dependence of γ on experimental protein concentrations or other sensitivity factors in detecting interactions, and find experimental evidence to support the prediction.

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