Publications

(157) Philip C. Hogan, Chi-Li Chen, Kristen M. Mulvihill, Jonathan F. Lawrence, Eric Moorhead, Jens Rickmeier, and Andrew G. Myers. Large-scale Preparation of Key Building Blocks for the Manufacture of Fully Synthetic Macrolide Antibiotics. Journal of Antibiotics (Tokyo). 2017; doi:10.1038/ja.2017.116.

(156) Fan Liu, Peter M. Wright, and Andrew G. Myers. Diastereoselective Michael–Claisen Cyclizations of γ-Oxa-α,β-unsaturated Ketones en Route to 5-Oxatetracyclines. Organic Letters. 2017; 19(1): 206–209.

(155) Vibeke Andresen, Bjarte S. Erikstein, Herschel Mukherjee, André Sulen, Mihaela Popa, Steinar Sørnes, Håkon Reikvam, Kok-Ping Chan, Randi Hovland, Emmet McCormack, Øystein Bruserud, Andrew G. Myers, and Bjørn T. Gjertsen. Anti-proliferative Activity of the NPM1 Interacting Natural Product Avrainvillamide in Acute Myeloid LeukemiaCell Death and Disease. 2016; 7(12): e2497. doi: 10.1038/cddis.2016.392.

(154) Ian B. Seiple, Ziyang Zhang, Pavol Jakubek, Audrey Langlois-Mercier, Peter M. Wright, Daniel T. Hog, Kazuo Yabu, Senkara Rao Allu, Takehiro Fukuzaki, Peter N. Carlsen, Yoshiaki Kitamura, Xiang Zhou, Matthew L. Condakes, Filip T. Szczypiński, William D. Green, and Andrew G. Myers. A Platform for the Discovery of New Macrolide AntibioticsNature. 2016: 533(7603): 338–345.

(153) Fan Liu and Andrew G. Myers. Development of a Platform for the Discovery and Practical Synthesis of New Tetracycline Antibiotics. Current Opinion in Chemical Biology. 2016; 32: 48–57.

(152) Ziyang Zhang, Takehiro Fukuzaki, and Andrew G. Myers. Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars. Angewandte Chemie International Edition. 2016; 55(2): 523–527.

(151) Ian B. Seiple, Daniel T. Hog, and Andrew G. Myers. Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxypentan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics. Synlett. 2016; 27(1): 57–60.

(150) Ziyang Zhang, Yoshiaki Kitamura, and Andrew G. Myers. An Efficient Directed Claisen Reaction Allows for Rapid Construction of 5,6-Disubstituted 1,3-Dioxin-4-ones. Synthesis. 2015; 47(18): 2709–2712.

(149) Henry E. Pelish, Brian B. Liau, Ioana I. Nitulescu, Anupong Tangpeerachaikul, Zachary C. Poss, Diogo H. Da Silva, Brittany T. Caruso, Alexander Arefolov, Olugbeminiyi Fadeyi, Amanda L. Christie, Karrie Du, Deepti Banka, Elisabeth V. Schneider, Anja Jestel, Ge Zou, Chong Si, Christopher C. Ebmeier, Roderick T. Bronson, Andrei V. Krivtsov, Andrew G. Myers, Nancy E. Kohl, Andrew L. Kung, Scott A. Armstrong, Madeleine E. Lemieux, Dylan J. Taatjes, and Matthew D. Shair. Mediator Kinase Inhibition Further Activates Super-enhancer-associated Genes in AML. Nature. 2015; 526(7572): 273–276.

(148) Herschel Mukherjee, Kok-Ping Chan, Vibeke Andresen, Mariah L. Hanley, Bjørn T. Gjertsen, and Andrew G. Myers. Interactions of the Natural Product (+)-Avrainvillamide with Nucleophosmin and Exportin‑1 Mediate the Cellular Localization of Nucleophosmin and its AML-Associated Mutants. ACS Chemical Biology. 2015; 10(3): 855–863.

(147) Kevin Pröpper, Birger Dittrich, Daniel J. Smaltz, Thomas Magauer, and Andrew G. Myers. Crystalline Guanine Adducts of Natural and Synthetic Trioxacarcins Suggest a Common Biological Mechanism and Reveal a Basis for the Instability of Trioxicarcin A. Bioorganic & Medicinal Chemistry Letters. 2014; 24(18): 4410-4413.

(146) Peter M. Wright, Ian B. Seiple, and Andrew G. Myers. The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery. Angewandte Chemie International Edition. 2014; 53(34): 8840–8869.

(145) Ian B. Seiple, Jaron A.M. Mercer, Robin J. Sussman, Ziyang Zhang, and Andrew G. Myers. Stereocontrolled Synthesis of syn-β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide. Angewandte Chemie International Edition. 2014; 53(18): 4642–4647.

(144)  Landy K. Blasdel, DongEun Lee, Binyuan Sun, and Andrew G. Myers. (S)-4-Trimethylsilyl-3-butyn-2-ol as an Auxiliary for Stereocontrolled Synthesis of Salinosporamide Analogs with Modifications at Positions C2 and C5. Bioorganic & Medicinal Chemistry Letters. 2013; 23(24): 6905–6910.

(143)  Kevin T. Mellem and Andrew G. Myers. A Simple, Scalable Synthetic Route to (+)- and (–)-Pseudoephenamine. Organic Letters. 2013; 15(21): 5594–5597.

(142)  Thomas Magauer, Daniel J. Smaltz, and Andrew G. Myers. Component-based Syntheses of Trioxacarcin A, DC-45-A1 and Structural Analogues. Nature Chemistry. 2013; 5(10): 886–893.

(141)  Cedric L. Hugelshofer, Kevin T. Mellem, and Andrew G. Myers. Synthesis of Quaternary α-Methyl α-Amino Acids by Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimine. Organic Letters. 2013; 15(12): 3134–3137.

(140)  Marvin R. Morales, Kevin T. Mellem, and Andrew G. Myers. Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis. Angewandte Chemie International Edition. 2012; 51(19): 4568–4571.

(139)  Daniel J. Smaltz, Jakub Švenda, and Andrew G. Myers. Diastereoselective Additions of Allylmetal Reagents to Free and Protected syn-α, β-Dihydroxyketones Enable Efficient Synthetic Routes to Methyl Trioxacarcinoside A. Organic Letters. 2012; 14(7): 1812–1815.

(138)  Peter M. Wright and Andrew G. Myers. Methodological Advances Permit the Stereocontrolled Construction of Diverse Fully Synthetic Tetracyclines Containing an All-Carbon Quaternary Center at Position C5a. Tetrahedron. 2011; 67(51): 9853–9869. 

(137)  Chong Si and Andrew G. Myers. A Versatile Synthesis of Substituted Isoquinolines. Angewandte Chemie International Edition. 2011; 50(44): 10409–10413.

(136)  Daniel J. Smaltz and Andrew G. Myers. Scalable Synthesis of Enantiomerically Pure syn-2,3-Dihydroxybutyrate by Sharpless Asymmetric Dihydroxylation of p-Phenylbenzyl Crotonate. Journal of Organic Chemistry. 2011; 76(20): 8554–8559. 

(135)  Thomas Magauer and Andrew G. Myers. Short and Efficient Synthetic Route to Methyl α-Trioxacarcinoside B and Anomerically Activated Derivatives. Organic Letters. 2011; 13(20): 5584–5587. 

(134)  Rebecca L. Simmons, Robert T. Yu, and Andrew G. Myers. Storable Arylpalladium(II) Reagents for Alkene Labeling in Aqueous Media. Journal of the American Chemical Society. 2011; 133(40): 15870–15873.

(133)  David A. Kummer, Derun Li, Amelie Dion, and Andrew G. Myers. A Practical, Convergent Route to the Key Precursor to the Tetracycline Antibiotics. Chemical Science. 2011; 2(9): 1710–1718. 

(132)  Jakub Švenda, Nicholas Hill, and Andrew G. Myers. A Multiply Convergent Platform for the Synthesis of Trioxacarcins. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(17): 6709–6714. 

(131)  Alec N. Flyer, Chong Si, and Andrew G. Myers. Synthesis of Cortistatins A, K, J, and L. Nature Chemistry. 2010; 2(10): 886–892.

(130)  Jakub Švenda and Andrew G. Myers. Anti-Selective Epoxidation of Methyl α-Methylene-β-tert-butyldimethylsiloxycarboxylate Esters. Evidence for Stereospecific Oxygen Atom Transfer in a Nucleophilic Epoxidation Process. Organic Letters. 2009; 11(11): 2437–2440.

(129)  Sang Min Lim, Nicholas Hill, and Andrew G. Myers. A Method for the Preparation of Differentiated trans-1,2-Diol Derivatives with Enantio- and Diastereocontrol. Journal of the American Chemical Society. 2009; 131(16): 5763–5765.

(128)  Cuixiang Sun, Qui Wang, Jason D. Brubaker, Peter M. Wright, Christian D. Lerner, Kevin Noson, Mark Charest, Dionicio R. Siegel, Yi-Ming Wang, and Andrew G. Myers. A Robust Platform for the Synthesis of New Tetracycline Antibiotics. Journal of the American Chemical Society. 2008; 130(52): 17913–17927.

(127)  David A. Kummer, William J. Chain, Marvin R. Morales, Olga Quiroga, and Andrew G. Myers. Stereocontrolled Alkylative Construction of Quaternary Carbon Centers. Journal of the American Chemical Society. 2008; 130(40): 13231–13233.

(126)  Jeremy E. Wulff, Romain Siegrist, and Andrew G. Myers. The Natural Product Avrainvillamide Binds to the Oncoprotein Nucleophosmin. Journal of the American Chemical Society. 2007; 129(46): 14444–14451.

(125)  Jason D. Brubaker and Andrew G. Myers. A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics. Organic Letters. 2007; 9(18): 3523–3525.

(124)  Feng Ren, Philip C. Hogan, Alan J. Anderson, and Andrew G. Myers. Synthesis of L-Kedarosamine in Protected Form and Its Efficient Incorporation into an Advanced Intermediate to Kedarcidin Chromophore. Organic Letters. 2007; 9(10): 1923–1925.

(123)  Feng Ren, Philip C. Hogan, Alan J. Anderson, and Andrew G. Myers. Kedarcidin Chromophore: Synthesis of Its Proposed Structure and Evidence for a Streochemical Revision. Journal of the American Chemical Society. 2007; 129(17): 5381–5383.

(122)  Jeremy E. Wulff, Seth B. Herzon, Romain Siegrist, and Andrew G. Myers. Evidence for the Rapid Conversion of Stephacidin B into the Electrophilic Monomer Avrainvillamide in Cell Culture. Journal of the American Chemical Society. 2007; 129(16): 4898–4899.

(121)  William J. Chain and Andrew G. Myers. A Convenient, NMR-Based Method for the Analysis of Diastereomeric Mixtures of Pseudoephedrine Amides. Organic Letters. 2007; 9(2): 355–357.

(120)  Thomas A. Dineen, Matthew A. Zajac, and Andrew G. Myers. Efficient Transamidation of Primary Carboxamides by in Situ Activation with N,N-Dialkylformamide Dimethyl Acetals. Journal of the American Chemical Society. 2006; 128(50): 16406–16409.

(119)  Nan Ji, Hardwin O'Dowd, Brad M. Rosen, and Andrew G. Myers. Enantioselective Synthesis of N1999A2. Journal of the American Chemical Society. 2006; 128(46): 14825–14827.

(118)  Jeffry R. Spencer, Martin Sendzik, Jason Oeh, Peter Sabbatini, Stacie A. Dalrymple, Catherine Magill, Hyunjin M. Kim, Penglie Zhang, Neil Squires, Katherine G. Moss, Juthamas Sukbuntherng, Doris Graupe, John Eksterowicz, Peter R. Young, Andrew G. Myers, and Michael J. Green. Evaluation of Antitumor Properties of Novel Saframycin Analogs in Vitro and in Vivo. Bioorganic and Medicinal Chemistry Letters. 2006; 16(18): 4884–4888.

(117)  Soojin Kwon and Andrew G. Myers. Synthesis of (–)-Quinocarcin by Directed Condensation of α-Amino Aldehydes. Journal of the American Chemical Society. 2005; 127(48): 16796–16797.

(116)  Landy K. Blasdel and Andrew G. Myers. Use of Lithium Hexafluoroisopropoxide as a Mild Base for Horner–Wadsworth–Emmons Olefination of Epimerizable Aldehydes. Organic Letters. 2005; 7(19): 4281–4283.

(115)  Daisuke Tanaka, Stuart P. Romeril, and Andrew G. Myers. On the Mechanism of the Palladium(II)-Catalyzed Decarboxylative Olefination of Arene Carboxylic Acids. Crystallographic Characterization of Non-Phosphine Palladium(II) Intermediates and Observation of their Stepwise Transformation in Heck-like Processes. Journal of the American Chemical Society. 2005; 127(9): 10323–10333.

(114)  Mark G. Charest, Dionicio R. Siegel, and Andrew G. Myers. Synthesis of (–)-Tetracycline. Journal of the American Chemical Society. 2005; 127(23): 8292–8293.

(113)  Seth B. Herzon and Andrew G. Myers. Enantioselective Synthesis of Stephacidin B. Journal of the American Chemical Society. 2005; 127(15): 5342–5344.

(112)  Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel, and Andrew G. Myers. A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics. Science. 2005; 308(5720): 395–398.

(111)  Nan Ji, Brad M. Rosen, and Andrew G. Myers. Method For the Rapid Synthesis of Highly Functionalized 2-Hydroxy-1-naphthoates. Syntheses of the Naphthoic Acid Components of Neocarzinostatin Chromophore and N1999A2. Organic Letters. 2004; 6(24): 4551–4553.

(110)   Michael E. Furrow and Andrew G. Myers. A General Procedure for the Esterification of Carboxylic Acids with Diazoalkanes Generated In Situ by the Oxidation of N-tert-Butyldimethylsilylhydrazones with (Difluoroiodo)benzene. Journal of the American Chemical Society. 2004; 126(39): 12222–12223.

(109)  Andrew M. Haidle and Andrew G. Myers. An Enantioselective, Modular, and General Route to the Cytochalasins: Synthesis of L-696,474 and Cytochalasin B. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(33): 12048–12053.

(108)  Michael E. Furrow and Andrew G. Myers. Practical Procedures for the Preparation of N-tert-Butyldimethylsilylhydrazones and Their Use in Modified Wolff–Kishner Reductions and in the Synthesis of Vinyl Halides and gem-Dihalides. Journal of the American Chemical Society. 2004; 126(17): 5436–5445.

(107)  Chengguo Xing, Jacob R. LaPorte, Joseph K. Barbay, and Andrew G. Myers. Identification of GAPDH as a Protein Target of the Saframycin Antiproliferative Agents. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(16): 5862–5866. 

(106)  Andrew G. Myers, Miki Sogi, Michael A. Lewis, and Stephen P. Arvedson. Synthetic and Theoretical Studies of Cyclobuta[1,2:3,4]dicyclopentene. Organocobalt Intermediates in the Construction of the Unsaturated Carbon Skeleton and Their Transformation into Novel Cobaltacyclic Complexes by C–C Insertion. The Journal of Organic Chemistry. 2004; 69(7): 2516–2525. 

(105)  Brian A. Lanman and Andrew G. Myers. Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines. Organic Letters. 2004; 6(6): 1045–1047.

(104)  Daisuke Tanaka and Andrew G. Myers. Heck-Type Arylation of 2-Cycloalken-1-ones with Arylpalladium Intermediates formed by Decarboxylative Palladation and by Aryl Iodide Insertion. Organic Letters. 2004; 6(3): 433–436.

(103)  Andrew G. Myers and Seth B. Herzon. Identification of a Novel Michael Acceptor Group for the Reversible Addition of Oxygen- and Sulfur-Based Nucleophiles. Synthesis and Reactivity of the 3-Alkylidene-3H-indole 1-Oxide Function of Avrainvillamide. Journal of the American Chemical Society. 2003; 125(40): 12080–12081.

(102)  Andrew G. Myers and Mohammad Movassaghi. o-Nitrobenzenesulfonylhydrazide. e-EROS Encyclopedia of Reagents for Organic Synthesis. 2003. 

(101)  Andrew G. Myers and Mark G. Charest. Pseudoephedrine. e-EROS Encyclopedia of Reagents for Organic Synthesis. 2003. 

(100) Andrew G. Myers and Brian A. Lanman. A Solid-Supported, Enantioselective Synthesis Suitable for the Rapid Preparation of Large Numbers of Diverse Structural Analogs of (–)-Saframycin A. Journal of the American Chemical Society. 2002; 124(44): 12969–12971.

(99)  Andrew G. Myers, Daisuke Tanaka, and Michael R. Mannion. Development of a Decarboxylative Palladation Reaction and its Use in a Heck-type Olefination of Arene Carboxylates. Journal of the American Chemical Society.  2002; 124(38): 11250–11251.

(98)  Andrew G. Myers and Michael Siu. Lewis Acid Mediated Control of Allylic Epoxide Opening in Carbocyclization and Halide Addition Pathways. Tetrahedron 2002; 58(32): 6397–6404.

(97)  Andrew G. Myers, Ralf Glatthar, Maryls Hammond, Phil Harrington, Elaine Y. Kuo, Jun Liang, Scott E. Schaus, Yusheng Wu, and Jia-Ning Xiang. Development of an Enantioselective Synthetic Route to Neocarzinostatin Chromophore and its use for Multiple Radioisotopic Incorporation. Journal of the American Chemical Society. 2002; 124(19): 5380–5401.

(96)  Alleyn T. Plowright, Scott E. Schaus, and Andrew G. Myers. Transcriptional Response Pathways in a Yeast Strain Sensitive to Saframycin A and a More Potent Analog: Evidence for a Common Basis of Activity. Chemistry and Biology. 2002; 9(5): 607–618.

(95)  Andrew G. Myers, Alexander R. Hurd, and Philip C. Hogan. Evidence for Facile Atropisomerism and Simple (Non-Nucleophilic) Biradical-Forming Cycloaromatization within Kedarcidin Chromophore Aglycon. Journal of the American Chemical Society. 2002; 124(17): 4583–4585.

(94)  Andrew G. Myers, Michael Siu, and Feng Ren. Enantioselective Synthesis of (–)-Terpestacin and (–)-Fusaproliferin: Clarification of Optical Rotational Measurements and Absolute Configurational Assignments Establishes a Homochiral Structural Series. Journal of the American Chemical Society. 2002; 124(16): 4230–4232.

(93)  Andrew G. Myers, Philip C. Hogan, Alexander R. Hurd, and Steven D. Goldberg. Enantioselective Synthesis of Kedarcidin Chromophore Aglycon in Differentially Protected Form. Angewandte Chemie International Edition. 2002; 41(6): 1062–1067.

(92)  Scott E. Schaus, Duccio Cavalieri, and Andrew G. Myers. Gene Transcription Analysis of Saccharomyces Cerevisiae Exposed to Neocarzinostatin Protein-Chromophore Complex Reveals Evidence of DNA Damage, a Potential Mechanism of Resistance, and Consequences of Prolonged Exposure. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(20): 11075–11080.

(91)  Andrew G. Myers, Dionicio R. Siegel, Daniel J. Buzard, and Mark G. Charest. Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions. Organic Letters. 2001; 3(18): 2923–2926.

(90)  Andrew G. Myers, Joseph K. Barbay, and Boyu Zhong. Asymmetric Synthesis of Chiral Organofluorine Compounds: Use of Nonracemic Fluoroidoacetic Acid as a Practical Electrophile and its Application to the Synthesis of Monofluoro Hydroxyethylene Dipeptide Isosteres within a Novel Series of HIV Protease Inhibitors. Journal of the American Chemical Society. 2001; 123(30): 7207–7219.

(89)  Andrew G. Myers and Alleyn T. Plowright. Synthesis and Evaluation of Bishydroquinone Derivatives of (–)-Saframycin A: Identification of a Versatile Molecular Template Imparting Potent Antiproliferative Activity.  Journal of the American Chemical Society. 2001; 123(21): 5114–5115.

(88)  Andrew G. Myers and Joseph K. Barbay. On the Inherent Instability of α-Amino α'-Fluoro Ketones. Evidence for Their Transformation to Reactive Oxyvinyliminium Ion Intermediates. Organic Letters. 2000; 3(3): 425–328.

(87)  Andrew G. Myers, Boyu Zhong, Daniel W. Kung, Mohammad Movassaghi, Brian A. Lanman, and Soojin Kwon. Synthesis of C-Protected α-Amino Aldehydes of High Enantiomeric Excess from Highly Epimerizable N-Protected α-Amino Aldehydes. Organic Letters. 2000; 2(21): 3337–3340.

(86)  Andrew G. Myers and Daniel W. Kung. One-Step Construction of the Pentacyclic Skeleton of Saframycin A from a "Trimer" of α-Amino Aldehydes. Organic Letters. 2000; 2(19): 3019–3022.

(85)  Andrew G. Myers and Steven D. Goldberg. Synthesis of the Kedarcidin Core Structure by a Transannular Cyclization Pathway. Angewandte Chemie International Edition. 2000; 39(15): 2732–2735.

(84)  Andrew G. Myers, Daniel W. Kung, and Boyu Zhong. Observations Concerning the Existence and Reactivity of Free α-Amino Aldehydes as Chemical Intermediates: Evidence for Epimerization-Free Adduct Formation with Various Nucleophiles. Journal of the American Chemical Society. 2000; 122(13): 3236–3237.

(83)  Andrew G. Myers, Boyu Zhong, Mohammad Movassaghi, Daniel W. Kung, Brian A. Lanman, and Soojin Kwon. Synthesis of Highly Epimerizable N-Protected α-Amino Aldehydes of High Enantiomeric Excess. Tetrahedron Letters. 2000; 41(9): 1359–1362.

(82)  Andrew G. Myers, Bryant H. Yang, and Hou Chen. Transformation of Pseudoephedrine Amides into Highly Enantiomerically Enriched Aldehydes, Alcohols, and Ketones. Organic Syntheses. 2000; 77: 29.

(81)  Andrew G. Myers and Bryant H. Yang. Synthesis and Diastereoselective Alkylation of Pseudoephedrine Amides. Organic Syntheses. 2000; 77: 22.

(80)  Andrew G. Myers and Daniel W. Kung. A Concise, Stereocontrolled Synthesis of (–)- Saframycin A by the Directed Condensation of α-Amino Aldehyde Precursors. Journal of the American Chemical Society. 1999; 121(46): 10828–10829.

(79)  Andrew G. Myers, Daniel W. Kung, Boyu Zhong, Mohammed Movassaghi, and Soojin Kwon. Preparation of Chiral, C-Protected α-Amino Aldehydes of High Optical Purity and Their Use as Condensation Components in a Linear Synthesis Strategy. Journal of the American Chemical Society. 1999; 121(36): 8401–8402. 

(78)  Andrew G. Myers, Jun Liang, and Marlys Hammond. Synthetic Replacement of the Methylamino Group of Neocarzinostatin Chromophore with Hydroxyl Prohibits Thiol Activation in Organic Solvents and Diminishes the Rate and Efficiency of Thiol-Promoted DNA Cleavage in Water. Tetrahedron Letters. 1999; 40(28): 5129–5133.

(77)  Andrew G. Myers and Bin Zheng. (tert-Butyldimethylsilyl)allene [Silane, (1,1-dimethylethyl)dimethyl-1,2-propadienyl-]. Organic Syntheses. 1999; 76: 178.

(76)  Andrew G. Myers and James L. Gleason. Asymmetric Synthesis of α-Amino Acids by the Alkylation of Pseudoephedrine Glycinamide: L-Allylglycine and N-Boc-L-allylglycine. Organic Syntheses. 1999; 76: 57.

(75)  Andrew G. Myers, Patrick Schnider, and Soojin Kwon, and Daniel W. Kung. Greatly Simplified Procedures for the Synthesis of α-Amino Acids by the Direct Alkylation of Pseudoephedrine Glycinamide Hydrate. The Journal of Organic Chemistry. 1999; 64(9): 3322–3327.

(74)  Andrew G. Myers and Mohammad Movassaghi. Highly Efficient Methodology for the Reductive Coupling of Aldehyde Tosylhydrazones with Alkyllithium Reagents. Journal of the American Chemical Society. 1998; 120(34): 8891–8892.

(73)  Andrew G. Myers and Steven D. Goldberg. Concise Synthesis of the Bicyclic Core of the Chromoprotein Antibiotics Kedarcidin and Neocarzinostatin by Transannular Reductive Cyclization of a Tetrayne Precursor. Tetrahedron Letters. 1998; 39(52): 9633–9636. 

(72)  Andrew G. Myers, Jun Liang, Marlys Hammond, Philip M. Harrington, Yusheng Wu, and Elaine Kuo. Total Synthesis of (+)-Neocarzinostatin Chromophore. Journal of the American Chemical Society. 1998; 120(21): 5319–5320. 

(71)  Andrew G. Myers, Lydia McKinstry, Joseph K. Barbay, and James L. Gleason. Practical Methodology for the Asymmetric Synthesis of Organofluorine Compounds. Tetrahedron Letters. 1998; 39(11): 1335–1338.

(70)  Andrew G. Myers, Lydia McKinstry, and James L. Gleason. Synthesis of Tertiary Alkyl Fluoride Centers by Asymmetric C-C(F) Bond Formation. Tetrahedron Letters. 1997; 38(40): 7037–7040.

(69)  Andrew G. Myers, Mohammad Movassaghi, and Bin Zheng. Mechanistic Studies of the Free-Radical Fragmentation of Monoalkyl Diazenes. Tetrahedron Letters. 1997; 38(37): 6569–6572.

(68)  Andrew G. Myers, Bin Zheng, and Mohammad Movassaghi. Preparation of the Reagent o-Nitrobenzenesulfonylhydrazine. The Journal of Organic Chemistry. 1997; 62(21): 7507.
 
(67)  Andrew G. Myers, Mohammad Movassaghi, and Bin Zheng. Single-Step Process for the Reductive Deoxygenation of Unhindered Alcohols. Journal of the American Chemical Society. 1997; 119(36): 8572–8573.

(66)  Andrew G. Myers and Yoshiaki Horiguchi. Synthesis of the Naphthoic Acid Component of Kedarcidin Chromophore by Routes Employing Photochemical and Thermal Electrocyclic Ring Closure Reactions. 
Tetrahedron Letters. 1997; 38(25): 4363–4366.

(65)  Andrew G. Myers, Bryant H. Yang, Hou Chen, Lydia McKinstry, David J. Kopecky, and James L. Gleason. Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones. Journal of the American Chemical Society. 1997; 119(28): 6496–6511.

(64)  Andrew G. Myers, Norma J. Tom, Mark E. Fraley, Scott B. Cohen, and David J. Madar. A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability. Journal of the American Chemical Society. 1997; 119(26): 6072–6094.

(63)  Andrew G. Myers, Michael E. Kort, Scott B. Cohen, and Norma J. Tom. Enzymatic Activation of DNA Cleavage by Dynemicin A and Synthetic Analogs. Biochemistry. 1997; 36(13): 3903–3908.

(62)  Andrew G. Myers, Bryant H. Yang, Hou Chen, and David J. Kopecky. Asymmetric Synthesis of 1,3-Dialkyl-Substituted Carbon Chains of any Stereochemical Configuration by an Iterable Process. Synlett. 1997; 457–459.

(61)  Andrew G. Myers, Michael Kort, and Marlys Hammond. A Comparison of DNA Cleavage by Neocarzinostatin Chromophore and its Aglycone: Evaluating the Role of the Carbohydrate Residue. Journal of the American Chemical Society. 1997; 119(13): 2965–2972.

(60)  Andrew G. Myers, James L. Gleason, Taeyoung Yoon, and Daniel W. Kung. Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-Amino Acids. Journal of the American Chemical Society. 1997; 119(4): 656–673.

(59)  Kyoung-Hee Kim, Andrew G. Myers, and Douglas C. Rees. Three Dimensional Structure of Neocarzinostatin. Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. Eds. H. Maeda et al. Springer: Tokyo. 1997. 109–128.

(58)  Andrew G. Myers, Marlys Hammond, Yusheng Wu, Jia-Ning Xiang, Philip M. Harrington, and Elaine Y. Kuo. Enantioselective Synthesis of Neocarzinostatin Chromophore Aglycon. Journal of the American Chemical Society. 1996: 118(41): 10006–10007.

(57)  Andrew G. Myers and Bin Zheng. An Efficient Method for the Reductive Transposition of Allylic Alcohols. Tetrahedron Letters. 1996; 37(28): 4841–4844.

(56)  Andrew G. Myers, Bryant Yang, and David Kopecky. Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols. Tetrahedron Letters. 1996; 37(21): 3623–3626.

(55)  Andrew G. Myers, Marlys Hammond, and Yusheng Wu. An Improved Preparation of Highly Enantiomerically Enriched (R)-(+)-4-tert-Butyldimethylsiloxy-2-cyclopenten-1-one. Tetrahedron Letters. 1996; 37(18): 3083–3086.

(54)  Andrew G. Myers and Bin Zheng. New and Stereospecific Synthesis of Allenes in a Single Step from Propargylic Alcohols. Journal of the American Chemical Society. 1996; 118(18): 4492–4493.

(53)  Andrew G. Myers, Stephen P. Arvedson, and Robert W. Lee. A New and Unusual Pathway for the Reaction of Neocarzinostatin Chromophore with Thiols. Revised Structure of the Protein-Directed Thiol Adduct. Journal of the American Chemical Society. 1996; 118(19): 4725–4726.

(52)  Andrew G. Myers and Cynthia A. Parrish. DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element. Bioconjugate Chemistry. 1996; 7(3): 322–331.

(51)  Andrew G. Myers, Vijaya Subramanian, and Marlys Hammond. A Concise Synthesis of the Naphthoic Acid Component of Neocarzinostatin Chromophore Featuring a New Photocyclization Reaction. Tetrahedron Letters. 1996; 37(5): 587–590.

(50)  Andrew G. Myers and Lydia McKinstry. Practical Syntheses of Enantiomerically Enriched γ-Lactones and γ-Hydroxy Ketones by the Alkylation of Pseudoephedrine Amides with Epoxides and their Derivatives. The Journal of Organic Chemistry. 1996; 61(7): 2428–2440.

(49)  Andrew G. Myers and James L. Gleason. A Practical Synthesis of L-Azatyrosine. The Journal of Organic Chemistry. 1996; 61(2): 813–815.

(48) Andrew G. Myers and Taeyoung Yoon. Synthesis of Highly Enantiomerically Enriched N-Boc-α-amino Ketones from Pseudoephedrine N-Boc-α-amino Acid Amides. Tetrahedron Letters. 1995; 36(52): 9429–9432.

(47)  Andrew G. Myers and Peter S. Dragovich. Synthesis of Functionalized Enynes by Palladium/Copper-Catalyzed Coupling Reactions of Acetylenes with (Z)-2,3-Dibromopropenoic Acid Ethyl Ester: (Z)-2-Bromo-5-(Trimethylsilyl)-2-Penten-4-Ynoic Acid Ethyl Ester. Organic Syntheses. 1995; 72: 104. 

(46)  Andrew G. Myers, James L. Gleason, and Taeyoung Yoon. A Practical Method for the Synthesis of D- or L-α-Amino Acids by the Alkylation of (+)- or (–)-Pseudoephedrine Glycinamide. Journal of the American Chemical Society. 1995; 117(32): 8488–8489.

(45)  Andrew G. Myers, Taeyoung Yoon, and James L. Gleason. A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of α-Amino Acids. Tetrahedron Letters. 1995; 36(26): 4555–4558.

(44)  Andrew G. Myers, Scott B. Cohen, Norma J. Tom, David J. Madar, and Mark E. Fraley. Insights into the Mechanism of DNA Cleavage by Dynemicin A as Revealed by DNA-Binding and -Cleavage Studies of Synthetic Analogs. Journal of the American Chemical Society. 1995; 117(28): 7574–7575.

(43)  Andrew G. Myers, Mark E. Fraley, Norma J. Tom, Scott B. Cohen, and David J. Madar. Synthesis of (+)-Dynemicin A and Analogs of Wide Structural Variability: Establishment of the Absolute Configuration of Natural Dynemicin A. Chemistry and Biology. 1995; 2(1): 33–43.

(42)  Andrew G. Myers and Kevin R. Condroski. Synthesis of (±)-7,8-Epoxy-4-basmen-6-one by a Transannular Cyclization Strategy. Journal of the American Chemical Society. 1995; 117(11): 3057–3083.

(41)  Andrew G. Myers, Mark E. Fraley, and Norma J. Tom. Highly Convergent Route to Dynemicins of Wide Structural Variability. Enantioselective Synthesis of Quinone Imine Precursors to Natural and Nonnatural Dynemicins. Journal of the American Chemical Society. 1994; 116(25): 11556–11557.

(40)  Andrew G. Myers, Bryant H. Yang, Hou Chen, and James L. Gleason. Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis. Journal of the American Chemical Society. 1994; 116(20): 9361–9362.

(39)  Andrew G. Myers, David Y. Gin, and Daniel H. Rogers. Synthetic Studies of the Tunicamycin Antibiotics. Preparation of (+)-Tunicaminyluracil, (+)-Tunicamycin-V, and 5'-epi-Tunicamycin-V. 
Journal of the American Chemical Society. 1994; 116(11): 4697–4718.

(38)  Andrew G. Myers, Scott B. Cohen, and Byoung-Mog Kwon. DNA Cleavage by Neocarzinostatin Chromophore. Establishing the Intermediacy of Chromophore-Derived Cumulene and Biradical Species and Their Role in Sequence-Specific Cleavage. Journal of the American Chemical Society. 1994; 116(5): 1670–1682.

(37)  Andrew G. Myers, Scott B. Cohen, and Byoung-Mog Kwon. A Study of the Reaction of Calicheamicin γ1 with Glutathione in the Presence of Double-Stranded DNA. Journal of the American Chemical Society.  1994; 116(4): 1255–1271.

(36)  Kyoung-Hee Kim, Byoung-Mog Kwon, Andrew G. Myers, and Douglas Rees. Crystal Structure of Neocarzinostatin, an Antitumor Protein-Chromophore Complex. Science. 1993; 262(5136): 1042–1046.

(35)  Andrew G. Myers and Kevin R. Condroski. Synthesis of (±)-7,8-Epoxy-4-basmen-6-one by a Transannular Cyclization Strategy. Journal of the American Chemical Society. 1993; 115(17): 7926–7927.

(34)  Andrew G. Myers and Peter S. Dragovich. A Reaction Cascade Leading to 1,6-Didehydro[10]annulene 1,5-Dehydronaphthalene Cyclization Initiated by Thiol Addition. Journal of the American Chemical Society. 1993; 115(15): 7021­–7022.

(33) Andrew G. Myers, David Y. Gin, and Daniel H. Rogers. A Convergent Synthetic Route to the Tunicamycin Antibiotics. Synthesis of (+)-Tunicamycin V. Journal of the American Chemical Society. 1993; 115(5): 2036–2038.
 
(32)  Richard E. Marsh, William P. Schaefer, Susan E. Kephart, and Andrew G. Myers. Structure of a syn-Aldol Addition Product of Benzaldehyde and A Prolinol-Derived O-Silacyclopentyl Ketene N,O-Acetal. Acta Crystallographica Section C: Crystal Structure Communications. 1993; C49: 185–188.

(31)  Andrew G. Myers and Nathaniel S. Finney. Synthesis of 1,6-Didehydro[10]annulene. Observation of its Exceptionally Facile Rearrangement to Form the Biradical 1,5-Dehydronaphthalene. Journal of the American Chemical Society. 1992; 114(27): 10986–10987.

(30)  Andrew G. Myers, Susan E. Kephart, and Hou Chen. Silicon-Directed Aldol Reactions. Rate Acceleration by Small Rings. Journal of the American Chemical Society. 1992; 114(20): 7922–7923.

(29)  Andrew G. Myers, Peter S. Dragovich, and Elaine Y. Kuo. Studies on the Thermal Generation and Reactivity of a Class of (σ,π)-1,4-Biradicals. Journal of the American Chemical Society. 1992; 114(24): 9369–9368.

(28)  Andrew G. Myers and Peter S. Dragovich. Design and Synthesis of a System for Enediyne Formation by Anthraquinone Reductive Activation. Journal of the American Chemical Society. 1992; 114(14): 5859–5860.

(27)  Andrew G. Myers, Katherine L. Widdowson, and Paivi J. Kukkola. Silicon-Directed Aldol Condensation. Evidence for a Pseudorotational Mechanism. Journal of the American Chemical Society. 1992; 114(7): 2765–2767.
 
(26)  William P. Schaefer, Vijaya Subramanian, and Andrew G. Myers. Structure of an 11-Membered Cyclic Silyl Enol Ether from Condensation of Methacrolein and a Pseudoephedrine-Derived O-Silyl Ketene N,O-Acetal. Acta Crystallographica Section C: Crystal Structure Communications. 1992; C48: 2090–2092.

(25)  Andrew G. Myers, Philip M. Harrington, and Byoung-Mog Kwon. Evidence for Aminoglycoside Participation in Thiol Activation of Neocarzinostatin Chromophore. Synthesis and Reactivity of the Epoxy Dienediyne Core. Journal of the American Chemical Society. 1992; 114(3): 1086–1087.

(24)  Richard E. Marsh, William P. Schaefer, Katherine L. Widdowson, and Andrew G. Myers. Structure of an anti-Aldol Addition Product of Benzaldehyde and a Pseudoephedrine-Derived O-Silyl Ketene N,O-Acetal. Acta Crystallographica Section C: Crystal Structure Communications. 1992; C48: 1948–1951. 

(23)  Richard E. Marsh, William P. Schaefer, Paivi J. Kukkola, and Andrew G. Myers. A Chiral N-Crotonyloxazolidinone Diels–Alder Adduct. Acta Crystallographica Section C: Crystal Structure Communications. 1992; C48: 1622–1624. 

(22)  Andrew G. Myers, David Y. Gin, and Katherine L. Widdowson. Silicon-mediated Reductive Coupling of Aldehydes and Allylic Alcohols. A Stereoselective Synthesis of Tunicaminyluracil. Journal of the American Chemical Society. 1991; 113(25): 9661–9663.

(21)  William P. Schaefer, Elaine Y. Kuo, Philip M. Harrington, and Andrew G. Myers.  Structure of a Chiral Cyclopentanone Precursor in Neocarzinostatin Synthetic Studies, C20H21NO3S.H2O. Acta Crystallographica Section C: Crystal Structure Communications. 1991; C47: 2578–2580.

(20)  William P. Schaefer, Katherine L. Widdowson, and Andrew G. Myers. Structures of Two Diastereomeric Aldol Products from a New Silicon-Directed Condensation. Acta Crystallographica Section C: Crystal Structure Communications. 1991; C47: 2575–2578.

(19)  Andrew G. Myers, Philip M. Harrington, and Elaine Y. Kuo. Enantioselective Synthesis of the Epoxydiyne Core of Neocarzinostatin Chromophore. Journal of the American Chemical Society. 1991; 113(2): 694–695.

(18)  Andrew G. Myers and Katherine L. Widdowson. A Silicon-Directed Aldol Condensation. Synthesis of Enantiomerically Pure Anti Aldols. Journal of the American Chemical Society. 1990; 112(26): 9672–9674.

(17)  Andrew G. Myers and Nathaniel S. Finney. Direct Observation and Retro-ene Reaction of a Propargylic Diazene. Stereochemical Assignment of Monoalkyl Diazenes. Journal of the American Chemical Society. 1990; 112(26): 9641–9643.

(16)  Andrew G. Myers and Paivi J. Kukkola. Stereoselective Synthesis of Olefins from Silylated Sulfonylhydrazones. Journal of the American Chemical Society. 1990; 112(22): 8208–8210.

(15)  Andrew G. Myers and Peter S. Dragovich. Design and Dynamics of a Chemically Triggered Reaction Cascade Leading to Biradical Formation at Subambient Temperature. Journal of the American Chemical Society. 1989; 111(25): 9130–9132.

(14)  Andrew G. Myers, Mian M. Alauddin, Mary Ann M. Fuhry, Peter S. Dragovich, Nathaniel S. Finney, and Philip M. Harrington. Versatile Precursors for the Synthesis of Enynes and Enediynes. Tetrahedron Letters. 1989; 30(50): 6997–7000.

(13)  Andrew G. Myers, Nathaniel S. Finney, and Elaine Y. Kuo. Allene Synthesis from 2-Alkyn-1-ols. Tetrahedron Letters. 1989; 30(42): 5747–5750.

(12)  Andrew G. Myers, Elaine Y. Kuo, and Nathaniel S. Finney. Thermal Generation of a α,3-Dehydrotoluene from (Z)-1,2,4-Heptatrien-6-yne. Journal of the American Chemical Society. 1989; 111(20): 8057–8059.

(11)  Andrew G. Myers and Philip J. Proteau. Evidence for Spontaneous, Low-Temperature Biradical Formation from a Highly Reactive Neocarzinostatin Chromophore-Thiol Conjugate. Journal of the American Chemical Society. 1989; 111(3): 1146–1147.

(10)  Andrew G. Myers and Katherine L. Widdowson. Direct Transformation of 2,3-Epoxy Alcohols into Hydroxy Carbonates Under Mildly Basic Conditions. Tetrahedron Letters. 1988; 29(49): 6389–6392.

(9)  Andrew G. Myers, Mary Ann M. Fundy, and Peter A. Lindstrom, Jr. Mild Conditions for the Removal of Acid-Labile Protective Groups. Tetrahedron Letters. 1988; 29(44): 5609–5612.

(8)  Andrew G. Myers, Philip J. Proteau, and Tracy M. Handel. Stereochemical Assignment of Neocarzinostatin Chromophore. Structures of Neocarzinostatin Chromophore-Methyl Thioglycolate Adducts. Journal of the American Chemical Society. 1988; 110(21): 7212–7214.

(7)  Andrew G. Myers. Proposed Structure of the Neocarzinostatin Chromophore-Methyl Thioglycolate Adduct; A Mechanism for the Nucleophilic Activation of Neocarzinostatin. Tetrahedron Letters. 1987; 28(39): 4493–4496.

(6)  E.J. Corey, J. Gregory Reid, Andrew G. Myers, and Robert W. Hahl. Simple Synthetic Route to the Limonoid System. Journal of the American Chemical Society. 1987; 109(3): 918–919.

(5)  E.J. Corey, Andrew G. Myers, Nobutaka Takahashi, Hisakazu Yamane, and Helmut Schraudolf. Constitution of Antheridium-Inducing Factor of Anemia Phyllitidis. Tetrahedron Letters. 1986; 27(42): 5083–5084.

(4)  E. J. Corey and Andrew G. Myers. Total Synthesis of (±)-Antheridium-Inducing Factor of the Fern Anemia phyllitidis. Clarification of Stereochemistry. Journal of the American Chemical Society. 1985; 107(19): 5574–5576.

(3)  S. Spadari, F. Focher, C. Kuenzle, E. J. Corey, Andrew G. Myers, N. Hardt, A. Rebuzzini, and G. Pedrali-Noy. In Vivo Distribution and Activity of Aphidicolin on Dividing and Quiescent Cells. Antiviral Research. 1985; 5(2): 93–101.

(2)  E. J. Corey and Andrew G. Myers. Efficient Synthesis and Intramolecular Cyclopropanation of Unsaturated Diazoacetic Esters. Tetrahedron Letters. 1984; 25(33): 3559–3562.

(1)  William R. Roush and Andrew G. Myers. Antibiotic X-14547A: Total Synthesis of the Right-Hand Half. The Journal of Organic Chemistry. 1981; 46(7): 1509–1511.

PATENTS

(1)  U.S. Patent No. 5,488,131, issued January 30, 1996. Andrew G. Myers. "Synthesis of Compounds with Predetermined Chirality"

(2)  U.S. Letters Patent No. 5,760,237, issued June 2, 1998. Andrew G. Myers. "Synthesis of L-Azatryrosine Using Pseudoephedrine as as Chiral Auxiliary"

(3)  U.S. Patent Application Serial No. 08/811,826. Andrew G. Myers. "Dynemicin Analogs"

(4)  U.S. Patent No. 7,183,054. Andrew G. Myers. "Assay for Identifying Biological Targets of Polynucleotide-Binding Compounds"

(5)  U.S. Patent No. 6,809,099, issued October 26, 2004. Andrew G. Myers. "Saframycins, Analogues and Uses Thereof" / Japanese Patent Application Serial No. 2002-543487. Andrew G. Myers. "Saframycin, Analogues and Uses Thereof" / U.S. Patent No. 7,122,549, issued October 17, 2006. Andrew G. Myers. "Saframycin, Analogues and Uses Thereof" / U.S. Patent Application Serial No. 11/582,526. Andrew G. Myers. "Saframycin, Analogues and Uses Thereof" / European Patent Application No. 019877338.9. Andrew G. Myers. "Synthesis of Saframycin, Analogues, and Uses Thereof"

(6)  U.S. Patent Application Serial No. 11/133,789. Andrew G. Myers. "Synthesis of Tetracyclines and Analogues Thereof" / PCT International Application Serial No. US2005/17831. Andrew G. Myers. "Synthesis of Tetracyclines and Analogues Thereof" / European Patent Application No. 3864/KOLNP/2006. Andrew G. Myers. "Synthesis of Tetracyclines and Analogues Thereof" / PRC Patent Application No. 200580023494.4. Andrew G. Myers. "Synthesis of Tetracyclines and Analogues Thereof" / Australian Patent Application No. 2005244988. Andrew G. Myers. "Synthesis of Tetracyclines and Analogues Thereof"

(7)  PCT International Application Serial No. US2006/009749, WO2006/102097. Andrew G. Myers. "Synthesis of Avrainvillamide, Stephacidin G, and Analogues Thereof" / U.S. National Phase Patent Application No. 11/908,901. Andrew G. Myers. "Synthesis of Avrainvillamide, Stephacidin G, and Analogues Thereof" / EPC Application Serial No. 06738771.2-1211-US2006009749. Andrew G. Myers. "Synthesis of Avrainvillamide, Stephacidin G, and Analogues Thereof"

(8)  U.S. Patent Application No. 11/870,772. Andrew G. Myers. "Synthesis of Enone Intermediate"

(9)  U.S. Patent Application No. 61/174,185. Andrew G. Myers. "Synthesis of Tetracyclines and Intermediates Thereto"